Sunday, May 22, 2011

Notes Of Mesothelioma Information Index

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  2. ^ Ashrafian H, Athanasiou T, Yap J, DeSouza AC. Two-chamber intracardiac mesothelioma. Asian Cardiovasc Thorac Ann. 2005 Jun;13(2):184-6.
  3. ^ Eastbourne Today. "Woman's death from asbestos". Retrieved 2008-10-28.
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  5. ^ EBSCO database verified by URAC; accessed from Mount Sinai Hospital, New York
  6. ^ a b c d e Roggli VL, Sharma A, Butnor KJ, Sporn T, Vollmer RT (2002). "Malignant mesothelioma and occupational exposure to asbestos: a clinicopathological correlation of 1445 cases". Ultrastruct Pathol 26 (2): 55–65. doi:10.1080/01913120252959227. PMID 12036093.
  7. ^ Sporn TA and Roggli VL: Mesothelioma. In: Pathology of Asbestos-associated Diseases, Second Edition (VL Roggli, TD Oury and TA Sporn, eds.), Springer 2004,pp104
  8. ^ Gennaro V et al. (2000). "Mesothelioma and Lung Tumors Attributable to Asbestos among Petroleum Workers". Am J Ind Med 37: 257–282.
  9. ^ Selikoff IJ: Occupational Respiratory Diseases. In: Public Health and Preventative Medicine, Twelfth Edition (Last J ed.), Appleton-Century-Crofts, 1986, pp. 532
  10. ^ Henderson DW et al. (2004). "After Helsinki: A multidisciplinary review of the relationship between asbestos exposure and lung cancer, with emphasis on studies published during 1997-2004". Pathology 36 (6): 517–550. doi:10.1080/00313020400010955. PMID 15841689.
  11. ^ MacLachlan DS (2002). "SV40 in human tumors: new documents shed light on the apparent controversy". Anticancer Res 22 (6B): 3495–9. PMID 12552945.
  12. ^ NIOSH Working Group Paper from the Centers for Disease Control, 1980
  13. ^ Hillerdal G. Mesothelioma: Cases Associated with Non-occupational and Low Dose Exposures. Occup Environ Med, 1999;56:505-513
  14. ^ a b Peto J, Seidman H and Selikoff IJ. Mesothelioma Mortality in Asbestos Workers: Implications for Models of Carcinogenesis and Risk Assessment. Brit J Cancer, 1982;45:124-135
  15. ^ Burdorf A, Dahhan M, Swuste P (2003). "Occupational characteristics of cases with asbestos-related diseases in The Netherlands". Ann Occup Hyg 47 (6): 485–92. doi:10.1093/annhyg/meg062. PMID 12890657.
  16. ^ "Hygiene standards for airborne amosite asbestos dust. British Occupational Hygiene Society Committee on Hygiene Standards". Ann Occup Hyg 16 (1): 1–5. 1973. PMID 4775386.
  17. ^ Lanphear BP and Buncher CR. Latent Period for Malignant Mesothelioma of Occupational Origin. J Occup Med, 1992;4:718-721
  18. ^ Dogan, Umran (2003). "Mesothelioma in Cappadocian villages". Indoor and Built Environment (Ankara: Sage) 12 (6): 367–375. doi:10.1177/1420326X03039065. ISSN: 1420-326X. Retrieved 2008-03-04.
  19. ^ Carbone, Michelle; et al. (2007). "A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes". Nature Reviews Cancer 7 (2): 147–54. doi:10.1038/nrc2068. PMID 17251920. ISSN 1474-175X. Retrieved 2008-03-04.
  20. ^ Protecting Workers' Families: A Research Agenda. National Institute for Occupational Safety and Health. DHHS (NIOSH) Publication No. 2002-113.
  21. ^ Radiographic Abnormalities and Exposure to Asbestos-Contaminated Vermiculite in the Community of Libby, Montana, USA
  22. ^ Edwards JG, Abrams KR, Leverment JN et al. (2000). "Prognostic factors for malignant mesothelioma in 142 patients: validation of CALGB and EORTC prognostic systems". Thorax 55 (9): 731–735. doi:10.1136/thorax.55.9.731. PMC 1745842. PMID 10950889.
  23. ^ a b Ceresoli, GL, , Santoro A (July 2007). "Multidisciplinary treatment of malignant pleural mesothelioma". Oncologist 12 (7): 850–863. doi:10.1634/theoncologist.12-7-850. PMID 17673616.
  24. ^ Rusch, VW (October 1995). "A proposed new international TNM staging system for malignant pleural mesothelioma". Chest 12 (7): 895–897. PMID 7555126.
  25. ^ Robinson BW, Creaney J, Lake R et al. (July 2005). "Soluble mesothelin-related protein—a blood test for mesothelioma". Lung Cancer 49 Suppl 1: S109–11. doi:10.1016/j.lungcan.2005.03.020. PMID 15950789.
  26. ^ Beyer, HL, , Glover CL et al. (April 2007). "MESOMARK: a potential test for malignant pleural mesothelioma". Clinical Chemistry 53 (4): 666–672. doi:10.1373/clinchem.2006.079327. PMID 17289801.
  27. ^ "The Junkman's Answer to Terrorism: Use More Asbestos | Center for Media and Democracy". Prwatch.org. Retrieved 2010-08-20.
  28. ^ a b c Borasio P, Berruti A, Bille A, et al. Malignant pleural mesothelioma: clinicopathologic and survival characteristics in a consecutive series of 394 patients. Eur J Card Thor Surg 2008;33:307-313
  29. ^ Haber SE and Haber JM. Malignant Mesothelioma: A Clinical Study of 238 Cases. Ind Health, 2011;49:166-172
  30. ^ a b Sugarbaker DJ, Flores RM, Jaklitsch MT et al. (January 1999). "Resection margins, extrapleural nodal status, and cell type determine postoperative long-term survival in trimodality therapy of malignant pleural mesothelioma: results in 183 patients". J Thorac Cardiovasc Surg 117 (1): 54–63; discussion 63–5. doi:10.1016/S0022-5223(99)70469-1. PMID 9869758.
  31. ^ Vogelzang N, Rusthoven J, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003 Jul;21(14):2636-44
  32. ^ Santoro A, O'Brien M, Stahel R, Nackaerts K, Baas P, Karthaus M, et al. Pemetrexed plus cisplatin or pemetrexed plus carboplatin for chemonaïve patients with malignant pleural mesothelioma: results of the International Expanded Access Program. J Thorac Oncol. 2008 Jul;3(7):756-63.
  33. ^ Sugarbaker PH, Welch LS, Mohamed F, Glehen O (July 2003). "A review of peritoneal mesothelioma at the Washington Cancer Institute". Surg Oncol Clin N Am 12 (3): 605–21, xi. doi:10.1016/S1055-3207(03)00045-0. PMID 14567020.
    Online manual: Management of Peritoneal Surface Malignancy.
  34. ^ Richards WG, Zellos L, Bueno R, Jaklitsch MT, Janne PA, Chirieac LR, Sugarbaker DJ (July 2006). "Phase I to II study of pleurectomy/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma.". J Clin Oncol. 24 (10): 1561–7. doi:10.1016/S1055-3207(03)00045-0. PMID 14567020.
  35. ^ Pass HI; Temeck BK; Kranda K et al. (1998). "Preoperative tumor volume is associated with outcome in malignant pleural mesothelioma.". J Thorac Cardiovasc Surg 115: 310–7; discussion 317–8. doi:10.1016/S0022-5223(98)70274-0. PMID 9475525.
  36. ^ Sugarbaker, DJ (2006). "Macroscopic complete resection: the goal of primary surgery in multimodality therapy for pleural mesothelioma". J Thorac Oncol 1 (2): 175–176. doi:10.1097/01243894-200602000-00014. PMID 17409850.
  37. ^ Sugarbaker DJ, Jaklitsch MT, Bueno R et al. (2004). "Prevention, early detection, and management of complications after 328 consecutive extrapleural pneumonectomies.". J Thorac Cardiovasc Surg 128 (1): 138–146. doi:10.1016/j.jtcvs.2004.02.021. PMID 15224033.
  38. ^ Bianchi, C; Bianchi T (June 2007). "Malignant mesothelioma: global incidence and relationship with asbestos". Industrial Health 45 (3): 379–387. doi:10.2486/indhealth.45.379. PMID 17634686.
  39. ^ Robinson BW, Lake RA (October 2005). "Advances in malignant mesothelioma". The New England Journal of Medicine 353 (15): 1591–603. doi:10.1056/NEJMra050152. PMID 16221782.
  40. ^ "DB-397.0.REPORT.JN.ppt" (PDF). Retrieved 2010-08-20.
  41. ^ Lerner, Barron H. (2005-11-15). "McQueen's Legacy of Laetrile". New York Times. Retrieved May 12, 2010.
  42. ^ RTE radio 1, Playback, 8 December
  43. ^ u.tv
  44. ^ Irish singer Hennessy dies at 62 - BBC News - 11 December 2007
  45. ^ MP MacDougall dies after illness - BBC NEWS
  46. ^ Gould, Stephen Jay. "The Median Isn't the Message".
  47. ^ Kraus, Paul. "Surviving Mesothelioma and Other Cancers: A Patient's Guide".
  48. ^ ORTIZ V. FIBREBOARD CORP. (97-1704) 527 U.S. 815 (1999) had individual liability from a single corporation and its insurance carriers of nearly $2 billion.
  49. ^ ORTIZ V. FIBREBOARD CORP. (97-1704) 527 U.S. 815 (1999)
  50. ^ Wagner JC, Sleggs CA, Marchand P (October 1960). "Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province". Br J Ind Med. 17: 260–71. PMC 1038078. PMID 13782506.
  51. ^ Alastair J Moore, Robert J Parker, John Wiggins (2008). "Malignant mesothelioma". Orphanet Journal of Rare Diseases 3 (34): 1750–1172. doi:10.1186/1750-1172-3-34. PMC 2652430. PMID 19099560.
  52. ^ McNulty JC (December 1962). "Malignant pleural mesothelioma in an asbestos worker". Med J Aust 49 (2): 953–4. PMID 13932248.
  53. ^ "June Hancock Research Fund". Retrieved 2010-03-01.
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Legal Issues Of Mesothelioma

Main article: Asbestos and the law
The first lawsuits against asbestos manufacturers were in 1929. Since then, many lawsuits have been filed against asbestos manufacturers and employers, for neglecting to implement safety measures after the links between asbestos, asbestosis, and mesothelioma became known (some reports seem to place this as early as 1898). The liability resulting from the sheer number of lawsuits and people affected has reached billions of dollars.[48] The amounts and method of allocating compensation have been the source of many court cases, reaching up to the United States Supreme Court, and government attempts at resolution of existing and future cases. However, to date, the US Congress has not stepped in and there are no federal laws governing asbestos compensation.[49]
History
The first lawsuit against asbestos manufacturers was brought in 1929. The parties settled that lawsuit, and as part of the agreement, the attorneys agreed not to pursue further cases. In 1960, an article published by Wagner et al. was seminal in establishing mesothelioma as a disease arising from exposure to asbestos.[50] The article referred to over 30 case studies of people who had suffered from mesothelioma in South Africa. Some exposures were transient and some were mine workers. Prior to the use of advanced microscopy techniques, malignant mesothelioma was often diagnosed as a variant form of lung cancer.[51] In 1962 McNulty reported the first diagnosed case of malignant mesothelioma in an Australian asbestos worker.[52] The worker had worked in the mill at the asbestos mine in Wittenoom from 1948 to 1950.
In the town of Wittenoom, asbestos-containing mine waste was used to cover schoolyards and playgrounds. In 1965 an article in the British Journal of Industrial Medicine established that people who lived in the neighbourhoods of asbestos factories and mines, but did not work in them, had contracted mesothelioma.
Despite proof that the dust associated with asbestos mining and milling causes asbestos-related disease, mining began at Wittenoom in 1943 and continued until 1966. In 1974 the first public warnings of the dangers of blue asbestos were published in a cover story called "Is this Killer in Your Home?" in Australia's Bulletin magazine. In 1978 the Western Australian Government decided to phase out the town of Wittenoom, following the publication of a Health Dept. booklet, "The Health Hazard at Wittenoom", containing the results of air sampling and an appraisal of worldwide medical information.
By 1979 the first writs for negligence related to Wittenoom were issued against CSR and its subsidiary ABA, and the Asbestos Diseases Society was formed to represent the Wittenoom victims.
In Leeds, England the Armley asbestos disaster involved several court cases against Turner & Newall where local residents who contracted mesothelioma claimed compensation because of the asbestos pollution from the company's factory. One notable case was that of June Hancock, who contracted the disease in 1993 and died in 1997.[53]
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Notable people who have lived for some time with mesothelioma

Although life expectancy with this disease is typically limited, there are notable survivors. In July 1982, Stephen Jay Gould was diagnosed with peritoneal mesothelioma. After his diagnosis, Gould wrote "The Median Isn't the Message"[46] for Discover magazine, in which he argued that statistics such as median survival are just useful abstractions, not destiny. Gould lived for another 20 years, eventually succumbing to metastatic adenocarcinoma of the lung, not mesothelioma. Author Paul Kraus was diagnosed with peritoneal mesothelioma in July 1997. He was given a prognosis of less than a year to live and used a variety of complementary modalities. He continues to outlive his prognosis and wrote a book about his experience "Surviving Mesothelioma and Other Cancers: A Patient's Guide"[47] in which he presented his philosophy about healing and the decision making that led him to use integrative medicine.
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Notable Cases Of Mesothelioma

Mesothelioma, though rare, has had a number of notable patients.
  • Hamilton Jordan, Chief of Staff for U.S. President Jimmy Carter and lifelong cancer activist, died in 2008.
  • Australian anti-racism activist Bob Bellear died in 2005.
  • British science fiction writer Michael G. Coney, responsible for nearly 100 works, also died in 2005.
  • American film and television actor Paul Gleason, perhaps best known for his portrayal of Principal Richard Vernon in the 1985 film The Breakfast Club, died in 2006.
  • Mickie Most, an English record producer, died of mesothelioma in 2003.
  • Bernie Banton, an Australian workers' rights activist, fought a long battle for compensation from James Hardie after he contracted mesothelioma after working for that company. He claimed James Hardie knew of the dangers of asbestos before he began work with the substance making insulation for power stations. Mesothelioma eventually took his life along with his brothers and hundreds of James Hardie workers. James Hardie made an undisclosed settlement with Banton only when his mesothelioma had reached its final stages and he was expected to have no more than 48 hours to live. Australian Prime Minister Kevin Rudd mentioned Banton's extended struggle in his acceptance speech after winning the 2007 Australian federal election.
  • Actor Steve McQueen was diagnosed with peritoneal mesothelioma on December 22, 1979. He was not offered surgery or chemotherapy because doctors felt the cancer was too advanced. McQueen subsequently sought alternative treatments at clinics in Mexico. He died of a heart attack on November 7, 1980, in Juárez, Mexico, following cancer surgery. He may have been exposed to asbestos while serving with the U.S. Marines as a young adult—asbestos was then commonly used to insulate ships' piping—or from its use as an insulating material in automobile racing suits (McQueen was an avid racing driver and fan).[41]
  • United States Congressman Bruce Vento died of mesothelioma in 2000. The Bruce Vento Hopebuilder award is given yearly by his wife at the MARF Symposium to persons or organizations who have done the most to support mesothelioma research and advocacy.
  • Rock and roll musician and songwriter Warren Zevon, after a long period of untreated illness and pain, was diagnosed with inoperable mesothelioma in the fall of 2002. Refusing treatments that he believed might incapacitate him, Zevon focused his energies on recording his final album The Wind, including the song "Keep Me in Your Heart," which speaks of his failing breath. Zevon died at his home in Los Angeles, California, on September 7, 2003.
  • Christie Hennessy, the influential Irish singer-songwriter, died of mesothelioma in 2007, and had stridently refused to accept the prognosis in the weeks before his death.[42] Hennessy's mesothelioma has been attributed to his younger years spent working on building sites in London.[43][44]
  • Australian journalist and news presenter Peter Leonard of Canberra succumbed to the condition on September 23, 2008.
  • Terrence McCann, Olympic gold medalist and longtime Executive Director of Toastmasters, died of mesothelioma on June 7, 2006, at his home in Dana Point, California.
  • Merlin Olsen, Pro Football Hall of Famer and television actor, died on March 10, 2010, from mesothelioma that had been diagnosed in 2009.
Posted by SUDARNO at 8:25 AM 0 comments
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Epidemiology Of Mesothelioma

Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. The incidence rate varies from one country to another, from a low rate of less than 1 per 1,000,000 in Tunisia and Morocco, to the highest rate in Britain, Australia and Belgium: 30 per 1,000,000 per year.[38] For comparison, populations with high levels of smoking can have a lung cancer incidence of over 1,000 per 1,000,000. Incidence of malignant mesothelioma currently ranges from about 7 to 40 per 1,000,000 in industrialized Western nations, depending on the amount of asbestos exposure of the populations during the past several decades.[39] It has been estimated that incidence may have peaked at 15 per 1,000,000 in the United States in 2004. Incidence is expected to continue increasing in other parts of the world. Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age. Approximately one fifth to one third of all mesotheliomas are peritoneal.
Between 1940 and 1979, approximately 27.5 million people were occupationally exposed to asbestos in the United States.[40] Between 1973 and 1984, the incidence of pleural mesothelioma among Caucasian males increased 300%. From 1980 to the late 1990s, the death rate from mesothelioma in the USA increased from 2,000 per year to 3,000, with men four times more likely to acquire it than women. These rates may not be accurate, since it is possible that many cases of mesothelioma are misdiagnosed as adenocarcinoma of the lung, which is difficult to differentiate from mesothelioma.
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Multimodality Therapy Of Mesothelioma

All of the standard approaches to treating solid tumors—radiation, chemotherapy, and surgery—have been investigated in patients with malignant pleural mesothelioma. Although surgery, by itself, is not very effective, surgery combined with adjuvant chemotherapy and radiation (trimodality therapy) has produced significant survival extension (3–14 years) among patients with favorable prognostic factors.[30] However, other large series of examining multimodality treatment have only demonstrated modest improvement in survival (median survival 14.5 months and only 29.6% surviving 2 years).[28] Reducing the bulk of the tumor with cytoreductive surgery is key to extending survival. Two surgeries have been developed: extrapleural pneumonectomy and pleurectomy/decortication. The indications for performing these operations are unique. The choice of operation depends on the size of the patient's tumor. This is an important consideration because tumor volume has been identified as a prognostic factor in mesothelioma.[35] Pleurectomy/decortication spares the underlying lung and is performed in patients with early stage disease when the intention is to remove all gross visible tumor (macroscopic complete resection), not simply palliation.[36] Extrapleural pneumonectomy is a more extensive operation that involves resection of the parietal and visceral pleurae, underlying lung, ipsilateral diaphragm, and ipsilateral pericardium. This operation is indicated for a subset of patients with more advanced tumors, who can tolerate a pneumonectomy.[37]
Posted by SUDARNO at 8:23 AM 0 comments
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Heated Intraoperative Intraperitoneal Chemotherapy Of Mesothelioma

A procedure known as heated intraoperative intraperitoneal chemotherapy was developed by Paul Sugarbaker at the Washington Cancer Institute.[33] The surgeon removes as much of the tumor as possible followed by the direct administration of a chemotherapy agent, heated to between 40 and 48°C, in the abdomen. The fluid is perfused for 60 to 120 minutes and then drained.
This technique permits the administration of high concentrations of selected drugs into the abdominal and pelvic surfaces. Heating the chemotherapy treatment increases the penetration of the drugs into tissues. Also, heating itself damages the malignant cells more than the normal cells.
This technique is also used in patients with malignant pleural mesothelioma.[34]
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